<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spfp</journal-id><journal-title-group><journal-title xml:lang="ru">Хранение и переработка сельхозсырья</journal-title><trans-title-group xml:lang="en"><trans-title>Storage and Processing of Farm Products</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-9669</issn><issn pub-type="epub">2658-767X</issn><publisher><publisher-name>РОСБИОТЕХ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36107/spfp.2023.417</article-id><article-id custom-type="elpub" pub-id-type="custom">spfp-417</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОЕКТИРОВАНИЕ И МОДЕЛИРОВАНИЕ ПРОДУКТОВ ПИТАНИЯ НОВОГО ПОКОЛЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DESIGNING AND MODELLING THE NEW GENERATION FOODS</subject></subj-group></article-categories><title-group><article-title>Эмульсии Пикеринга на основе модифицированных полисахаридов бурых водорослей для получения пищевых систем нового поколения</article-title><trans-title-group xml:lang="en"><trans-title>Pickering Emulsions Based on Modified Brown Algae Polysaccharides for the Production of New Generation Food Systems</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3059-8061</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потороко</surname><given-names>Ирина Юрьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Potoroko</surname><given-names>Irina Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор технических наук, профессор, и.о. директора высшей медико-биологической школы, зав. кафедрой пищевых и биотехнологий, Южно-Уральский государственный университет (НИУ)</p></bio><email xlink:type="simple">potorokoii@susu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2755-1497</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кади</surname><given-names>Аммар Мохаммад</given-names></name><name name-style="western" xml:lang="en"><surname>Kadi</surname><given-names>Ammar M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры пищевых и биотехнологий, Южно-Уральский государственный университет (НИУ)</p></bio><email xlink:type="simple">ammarka89@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4981-717X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паймулина</surname><given-names>Анастасия Валерияновна</given-names></name><name name-style="western" xml:lang="en"><surname>Paymulina</surname><given-names>Anastasiya V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат технических наук, ведущий научный сотрудник отдела пищевых систем и биотехнологий СФНЦА РАНМладший научный сотрудник управления научной и инновационной деятельности, Южно-Уральский государственный университет (НИУ)</p></bio><email xlink:type="simple">aaaminaaa@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9520-3251</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Науменко</surname><given-names>Наталья Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Naumenko</surname><given-names>Natalia V.</given-names></name></name-alternatives><email xlink:type="simple">Naumenko_natalya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Южно-Уральский государственный&#13;
университет (НИУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State University (National&#13;
Research University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Сибирский федеральный научный центр агробиотехнологий&#13;
Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian Federal Research Center of Agrobiotechnologies of the Russian&#13;
Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2023</year></pub-date><volume>0</volume><issue>1</issue><fpage>136</fpage><lpage>149</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Потороко И.Ю., Кади А.М., Паймулина А.В., Науменко Н.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Потороко И.Ю., Кади А.М., Паймулина А.В., Науменко Н.В.</copyright-holder><copyright-holder xml:lang="en">Potoroko I.Y., Kadi A.M., Paymulina A.V., Naumenko N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.spfp-mgupp.ru/jour/article/view/417">https://www.spfp-mgupp.ru/jour/article/view/417</self-uri><abstract><sec><title>Введение</title><p>Введение. Формирование сегмента продуктов питания нового поколения, обладающих устойчивыми функциональными свойствами связано с рядом проблем, обусловленными значительной вариативностью качества исходного сырья. Одним из путей реализации данного направления может стать использование эмульсии Пикеринга как матрицы для доставки пищевых биоактивных ингредиентов. В качестве стабилизирующих частиц перспективным является использование микроструктурированых растительных полисахаридов, что обусловливает актуальность представленных исследований.</p><p>Цель исследования — исследование применимости нетепловых эффектов ультразвука для модификации растительных полисахаридов, которые будут использоваться в качестве стабилизирующих частиц в технологии эмульсий, используемых при получении пищевых систем.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В качестве объектов исследования выступали образцы эмульсий Пикеринга с липидной фракцией на основе льняного масла холодного отжима из семян сорта селекции «Уральский», стабилизированные микроструктурированными Фукоиданом и альгинатом натрия (Alg—Na). Для микроструктурирования применены эффекты кавитации с параметрами: 22 ± 1,65 кГц и интенсивностью излучения не менее 10 Вт/см2.</p></sec><sec><title>Результаты</title><p>Результаты. В ходе исследования оценивали антиоксидантную активность, дисперсные характеристики и морфологические изменения структуры частиц, а также характер встраивания их в эмульсии Пикеринга. Установлены рациональные режимы микроструктурирования. Отмечено увеличение антирадикальной активности для Фукоидана — в 5,2 раза (630 Вт/л; 30 мин), для Alg—Na – в 7,4 раза (630 Вт/л; 18 мин). После сонохимического микроструктурирования микрочастицы полисахаридов по-разному укладываются в системе эмульсии Пикеринга, что влияет на их вязкость и устойчивость.</p></sec><sec><title>Выводы</title><p>Выводы. Представленные исследования подтверждают эффективность микроструктурирования полисахаридов бурых водорослей для стабилизирования эмульсий Пикеринга, что обеспечивает возможность их применения в технологии пищевых систем нового поколения. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The formation of a segment of a new generation of food products with stable functional properties is associated with a number of problems due to the significant variability in the quality of the feedstock. One of the ways to implement this direction can be the use of Pickering's emulsion as a matrix for the delivery of food bioactive ingredients. As stabilizing particles, the use of microstructured plant polysaccharides is promising, which determines the relevance of the presented studies.</p><p>Purpose of the study is to study the applicability of non-thermal ultrasound effects for the modification of plant polysaccharides, which will be used as stabilizing particles in the technology of emulsions used in the production of food systems.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. The objects of the study were samples of Pickering emulsions with a lipid fraction based on cold-pressed linseed oil «Uralsky», stabilized with microstructured Fucoidan and sodium alginate (Alg—Na). For microstructuring, cavitation effects are applied, generated by low-frequency ultrasound with a frequency of mechanical vibrations of 22 ± 1.65 kHz and a radiation intensity of at least 10 W/cm2.</p></sec><sec><title>Results</title><p>Results. During the study,the antioxidant activity,disperse characteristics and morphological changes in the structure of particles, as well as the nature of their incorporation into Pickering emulsions, were evaluated. Established rational modes of microstructuring. An increase in antiradical activity against DPPH was noted for fucoidan — 5.2 times (630 W/l; 30 min), for Alg—Na — 7.4 times (630 W/l; 18 min). After sonochemical microstructuring, polysaccharide microparticles stack differently in the Pickering emulsion system, which affects the viscosity and stability over time.</p></sec><sec><title>Conclusions</title><p>Conclusions. The presented studies confirm the effectiveness of sonochemical microstructuring of brown algae polysaccharides for stabilizing Pickering emulsions with proven bioactivity, which makes it possible to use them in the technology of food systems of a new generation</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эмульсии Пикеринга</kwd><kwd>микроструктурирование</kwd><kwd>полисахариды бурых водорослей</kwd><kwd>ультразвуковое воздействие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Pickering emulsions</kwd><kwd>microstructuring</kwd><kwd>brown algae polysaccharides</kwd><kwd>ultrasound exposure</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья выполнена при финансовой поддержке гранта РНФ 22-26-00079</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ashokkumar, M. Applications of ultrasound in food and bioprocessing. Ultrasonics Sonochemistry 2015, 25, 17–23. https://doi.org/10.1016/j.ultsonch.2014.08.012</mixed-citation><mixed-citation xml:lang="en">Ashokkumar, M. Applications of ultrasound in food and bioprocessing. Ultrasonics Sonochemistry 2015, 25, 17–23. https://doi.org/10.1016/j.ultsonch.2014.08.012</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Atashrazm F., Lowenthal R. M., Woods G. M., Holloway A. F., Dickinson J. L. (2015). Fucoidan and cancer: A multifunctional molecule with anti-tumor potential. Marine drugs, 13(4), 2327-2346. https://doi.org/10.3390/md13042327</mixed-citation><mixed-citation xml:lang="en">Atashrazm F., Lowenthal R. M., Woods G. M., Holloway A. F., Dickinson J. L. (2015). Fucoidan and cancer: A multifunctional molecule with anti-tumor potential. Marine drugs, 13(4), 2327-2346. https://doi.org/10.3390/md13042327</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Benslima, A., Sellimi, S., Hamdi, M., Nasri, R., Jridi, M., Cot, D., ... &amp; Zouari, N. (2021). The brown seaweed Cystoseira schiffneri as a source of sodium alginate: Chemical and structural characterization, and antioxidant activities. Food Bioscience, 40, 100873. https://doi.org/10.1016/j.fbio.2020.100873</mixed-citation><mixed-citation xml:lang="en">Benslima, A., Sellimi, S., Hamdi, M., Nasri, R., Jridi, M., Cot, D., ... &amp; Zouari, N. (2021). The brown seaweed Cystoseira schiffneri as a source of sodium alginate: Chemical and structural characterization, and antioxidant activities. Food Bioscience, 40, 100873. https://doi.org/10.1016/j.fbio.2020.100873</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cen, S., Li, Z., Guo, Z., Li, H., Shi, J., Huang, X., ... &amp; Holmes, M. (2022). 4D printing of a citrus pectin/β-CD Pickering emulsion: a study on temperature induced color transformation. Additive Manufacturing, 102925. https://doi.org/10.1016/j.addma.2022.102925</mixed-citation><mixed-citation xml:lang="en">Cen, S., Li, Z., Guo, Z., Li, H., Shi, J., Huang, X., ... &amp; Holmes, M. (2022). 4D printing of a citrus pectin/β-CD Pickering emulsion: a study on temperature induced color transformation. Additive Manufacturing, 102925. https://doi.org/10.1016/j.addma.2022.102925</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chen, Q. H., Zheng, J., Xu, Y. T., Yin, S. W., Liu, F., &amp; Tang, C. H. (2018). Surface modification improves fabrication of pickering high internal phase emulsions stabilized by cellulose nanocrystals. Food Hydrocolloids, 75, 125-130. https://doi.org/10.1016/j.foodhyd.2017.09.005</mixed-citation><mixed-citation xml:lang="en">Chen, Q. H., Zheng, J., Xu, Y. T., Yin, S. W., Liu, F., &amp; Tang, C. H. (2018). Surface modification improves fabrication of pickering high internal phase emulsions stabilized by cellulose nanocrystals. Food Hydrocolloids, 75, 125-130. https://doi.org/10.1016/j.foodhyd.2017.09.005</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Córdova, B. M., Jacinto, C. R., Alarcón, H., Mejía, I. M., López, R. C., de Oliveira Silva, D., Valderrama, A. C. (2018). Chemical modification of sodium alginate with thiosemicarbazide for the removal of Pb (II) and Cd (II) from aqueous solutions. International journal of biological macromolecules, 120, 2259-2270. https://doi.org/10.1016/j.ijbiomac.2018.08.095</mixed-citation><mixed-citation xml:lang="en">Córdova, B. M., Jacinto, C. R., Alarcón, H., Mejía, I. M., López, R. C., de Oliveira Silva, D., Valderrama, A. C. (2018). Chemical modification of sodium alginate with thiosemicarbazide for the removal of Pb (II) and Cd (II) from aqueous solutions. International journal of biological macromolecules, 120, 2259-2270. https://doi.org/10.1016/j.ijbiomac.2018.08.095</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cui, K., Tai, W., Shan, X., Hao, J., Li, G., &amp; Yu, G. (2018). Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens. International journal of biological macromolecules, 120, 1817-1822. https://doi.org/10.1016/j.ijbiomac.2018.09.079</mixed-citation><mixed-citation xml:lang="en">Cui, K., Tai, W., Shan, X., Hao, J., Li, G., &amp; Yu, G. (2018). Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens. International journal of biological macromolecules, 120, 1817-1822. https://doi.org/10.1016/j.ijbiomac.2018.09.079</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dhiman, A., &amp; Prabhakar, P. K. (2021). Micronization in food processing: A comprehensive review of mechanistic approach, physicochemical, functional properties and self-stability of micronized food materials. Journal of Food Engineering, 292, 110248. https://doi.org/10.1016/j.jfoodeng.2020.110248</mixed-citation><mixed-citation xml:lang="en">Dhiman, A., &amp; Prabhakar, P. K. (2021). Micronization in food processing: A comprehensive review of mechanistic approach, physicochemical, functional properties and self-stability of micronized food materials. Journal of Food Engineering, 292, 110248. https://doi.org/10.1016/j.jfoodeng.2020.110248</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gong, J., Wang, S., Wang, J., Feng, W., Peng, H., Tang, J., &amp; Yu, P. S. (2020, July). Attentional graph convolutional networks for knowledge concept recommendation in moocs in a heterogeneous view. In Proceedings of the 43rd International ACM SIGIR Conference on Research and Development in Information Retrieval (pp. 79-88). https://doi.org/10.1145/3397271.3401057</mixed-citation><mixed-citation xml:lang="en">Gong, J., Wang, S., Wang, J., Feng, W., Peng, H., Tang, J., &amp; Yu, P. S. (2020, July). Attentional graph convolutional networks for knowledge concept recommendation in moocs in a heterogeneous view. In Proceedings of the 43rd International ACM SIGIR Conference on Research and Development in Information Retrieval (pp. 79-88). https://doi.org/10.1145/3397271.3401057</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Heenu Sharma, Swati Sharma, Jasveen Bajwa, Riya Chugh, Deepak Kumar (2023) Polymeric carriers in probiotic delivery system Carbohydrate Polymer Technologies and Applications, 100301, https://doi.org/10.1016/j.carpta.2023.100301.</mixed-citation><mixed-citation xml:lang="en">Heenu Sharma, Swati Sharma, Jasveen Bajwa, Riya Chugh, Deepak Kumar (2023) Polymeric carriers in probiotic delivery system Carbohydrate Polymer Technologies and Applications, 100301, https://doi.org/10.1016/j.carpta.2023.100301.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hmelkov A.B. Zvyagintseva T.N., Shevchenko N.M. (2018) Ultrasound-assisted extraction of polysaccharides from brown alga Fucus evanescens. Structure and biological activity of the new fucoidan fractions Journal of Applied Phycology, 30(3), 2039–2046.</mixed-citation><mixed-citation xml:lang="en">Hmelkov A.B. Zvyagintseva T.N., Shevchenko N.M. (2018) Ultrasound-assisted extraction of polysaccharides from brown alga Fucus evanescens. Structure and biological activity of the new fucoidan fractions Journal of Applied Phycology, 30(3), 2039–2046.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Huang, M., Wang, J., &amp; Tan, C. (2021). Tunable high internal phase emulsions stabilized by cross-linking/electrostatic deposition of polysaccharides for delivery of hydrophobic bioactives. Food Hydrocolloids, 118, 106742. https://doi.org/10.1016/j.foodhyd.2021.106742</mixed-citation><mixed-citation xml:lang="en">Huang, M., Wang, J., &amp; Tan, C. (2021). Tunable high internal phase emulsions stabilized by cross-linking/electrostatic deposition of polysaccharides for delivery of hydrophobic bioactives. Food Hydrocolloids, 118, 106742. https://doi.org/10.1016/j.foodhyd.2021.106742</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Imbs, T. I., Ermakova, S. P. (2021). Can Fucoidans of Brown Algae Be Considered as Antioxidants?. Russian Journal of Marine Biology, 47(3), 157-161. https://doi.org/10.1134/S1063074021030056</mixed-citation><mixed-citation xml:lang="en">Imbs, T. I., Ermakova, S. P. (2021). Can Fucoidans of Brown Algae Be Considered as Antioxidants?. Russian Journal of Marine Biology, 47(3), 157-161. https://doi.org/10.1134/S1063074021030056</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jiao, B., Shi, A., Wang, Q., &amp; Binks, B. P. (2018). High‐internal‐phase pickering emulsions stabilized solely by peanut‐protein‐isolate microgel particles with multiple potential applications. Angewandte Chemie, 130(30), 9418-9422. https://doi.org/10.1002/ange.201801350</mixed-citation><mixed-citation xml:lang="en">Jiao, B., Shi, A., Wang, Q., &amp; Binks, B. P. (2018). High‐internal‐phase pickering emulsions stabilized solely by peanut‐protein‐isolate microgel particles with multiple potential applications. Angewandte Chemie, 130(30), 9418-9422. https://doi.org/10.1002/ange.201801350</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kiani, H., Zhang, Z., Delgado, A., &amp; Sun, D. W. (2011). Ultrasound assisted nucleation of some liquid and solid model foods during freezing. Food Research International, 44(9), 2915-2921. https://doi.org/10.1016/j.foodres.2011.06.051</mixed-citation><mixed-citation xml:lang="en">Kiani, H., Zhang, Z., Delgado, A., &amp; Sun, D. W. (2011). Ultrasound assisted nucleation of some liquid and solid model foods during freezing. Food Research International, 44(9), 2915-2921. https://doi.org/10.1016/j.foodres.2011.06.051</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Koh H. S. A., Lu J., Zhou W. (2019). Structure characterization and antioxidant activity of fucoidan isolated from Undaria pinnatifida grown in New Zealand. Carbohydrate polymers, 212, 178-185. https://doi.org/10.1016/j.carbpol.2019.02.040</mixed-citation><mixed-citation xml:lang="en">Koh H. S. A., Lu J., Zhou W. (2019). Structure characterization and antioxidant activity of fucoidan isolated from Undaria pinnatifida grown in New Zealand. Carbohydrate polymers, 212, 178-185. https://doi.org/10.1016/j.carbpol.2019.02.040</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kolodyńska D., Gęca M., Skwarek E., Goncharuk O. (2018). Titania-coated silica alone and modified by sodium alginate as sorbents for heavy metal ions. Nanoscale Research Letters, 13(1), 1-12. https://doi.org/10.1186/s11671-018-2512-7</mixed-citation><mixed-citation xml:lang="en">Kolodyńska D., Gęca M., Skwarek E., Goncharuk O. (2018). Titania-coated silica alone and modified by sodium alginate as sorbents for heavy metal ions. Nanoscale Research Letters, 13(1), 1-12. https://doi.org/10.1186/s11671-018-2512-7</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Krylova N. V., Ermakova S. P., Lavrov V. F., Leneva I. A., Kompanets G. G., Iunikhina O. V., Zaporozhets T. S. (2020). The comparative analysis of antiviral activity of native and modified fucoidans from brown algae Fucus evanescens in vitro and in vivo. Marine drugs, 18(4), 224. https://doi.org/10.3390/md18040224</mixed-citation><mixed-citation xml:lang="en">Krylova N. V., Ermakova S. P., Lavrov V. F., Leneva I. A., Kompanets G. G., Iunikhina O. V., Zaporozhets T. S. (2020). The comparative analysis of antiviral activity of native and modified fucoidans from brown algae Fucus evanescens in vitro and in vivo. Marine drugs, 18(4), 224. https://doi.org/10.3390/md18040224</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Lee J., Kim J., Moon C., Kim S. H., Hyun J. W., Park J. W., Shin T. (2008). Radioprotective effects of fucoidan in mice treated with total body irradiation. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(12), 1677-1681. https://doi.org/10.1002/ptr.2562</mixed-citation><mixed-citation xml:lang="en">Lee J., Kim J., Moon C., Kim S. H., Hyun J. W., Park J. W., Shin T. (2008). Radioprotective effects of fucoidan in mice treated with total body irradiation. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(12), 1677-1681. https://doi.org/10.1002/ptr.2562</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Li Q., Wu Y., Fang R., Lei C., Li Y., Li B., Luo X. (2021). Application of Nanocellulose as particle stabilizer in food Pickering emulsion: Scope, Merits and challenges. Trends in Food Science &amp; Technology, 110, 573-583. https://doi.org/10.1016/j.tifs.2021.02.027</mixed-citation><mixed-citation xml:lang="en">Li Q., Wu Y., Fang R., Lei C., Li Y., Li B., Luo X. (2021). Application of Nanocellulose as particle stabilizer in food Pickering emulsion: Scope, Merits and challenges. Trends in Food Science &amp; Technology, 110, 573-583. https://doi.org/10.1016/j.tifs.2021.02.027</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lin P., Chen S., Liao M., Wang W. (2022). Physicochemical Characterization of Fucoidans from Sargassum henslowianum C. Agardh and Their Antithrombotic Activity In Vitro. Marine Drugs, 20(5), 300. https://doi.org/10.3390/md20050300</mixed-citation><mixed-citation xml:lang="en">Lin P., Chen S., Liao M., Wang W. (2022). Physicochemical Characterization of Fucoidans from Sargassum henslowianum C. Agardh and Their Antithrombotic Activity In Vitro. Marine Drugs, 20(5), 300. https://doi.org/10.3390/md20050300</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Marefati A., Sjöö M., Timgren A., Dejmek P., Rayner M. (2015). Fabrication of encapsulated oil powders from starch granule stabilized W/O/W Pickering emulsions by freeze-drying. Food Hydrocolloids, 51, 261-271. https://doi.org/10.1016/j.foodhyd.2015.04.022</mixed-citation><mixed-citation xml:lang="en">Marefati A., Sjöö M., Timgren A., Dejmek P., Rayner M. (2015). Fabrication of encapsulated oil powders from starch granule stabilized W/O/W Pickering emulsions by freeze-drying. Food Hydrocolloids, 51, 261-271. https://doi.org/10.1016/j.foodhyd.2015.04.022</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mok T. S., Wu Y. L., Kudaba I., Kowalski D. M., Cho B. C., Turna H. Z., Lu S. (2019). Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial. The Lancet, 393(10183), 1819-1830. https://doi.org/10.1016/S0140-6736(18)32409-7</mixed-citation><mixed-citation xml:lang="en">Mok T. S., Wu Y. L., Kudaba I., Kowalski D. M., Cho B. C., Turna H. Z., Lu S. (2019). Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial. The Lancet, 393(10183), 1819-1830. https://doi.org/10.1016/S0140-6736(18)32409-7</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Peng Y., Song Y., Wang Q., Hu Y., He Y., Ren D., Zhou H. (2019). In vitro and in vivo immunomodulatory effects of fucoidan compound agents. International journal of biological macromolecules, 127, 48-56. https://doi.org/10.1016/j.ijbiomac.2018.12.197</mixed-citation><mixed-citation xml:lang="en">Peng Y., Song Y., Wang Q., Hu Y., He Y., Ren D., Zhou H. (2019). In vitro and in vivo immunomodulatory effects of fucoidan compound agents. International journal of biological macromolecules, 127, 48-56. https://doi.org/10.1016/j.ijbiomac.2018.12.197</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Perrin E., Bizot H., Cathala B., Capron I. (2014). Chitin nanocrystals for Pickering high internal phase emulsions. Biomacromolecules, 15(10), 3766-3771. https://doi.org/10.1021/bm5010417</mixed-citation><mixed-citation xml:lang="en">Perrin E., Bizot H., Cathala B., Capron I. (2014). Chitin nanocrystals for Pickering high internal phase emulsions. Biomacromolecules, 15(10), 3766-3771. https://doi.org/10.1021/bm5010417</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ribeiro E. F., Morell P., Nicoletti V. R., Quiles A., Hernando I. (2021). Protein-and polysaccharide-based particles used for Pickering emulsion stabilisation. Food Hydrocolloids, 119, 106839. https://doi.org/10.1016/j.foodhyd.2021.106839</mixed-citation><mixed-citation xml:lang="en">Ribeiro E. F., Morell P., Nicoletti V. R., Quiles A., Hernando I. (2021). Protein-and polysaccharide-based particles used for Pickering emulsion stabilisation. Food Hydrocolloids, 119, 106839. https://doi.org/10.1016/j.foodhyd.2021.106839</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Potoroko I.Yu., Kalinina I.V., Naumenko N.V., Fatkullin R.I., Nenasheva A.V., Uskova D.G., Sonawane S.H., Ivanova D.G., &amp;Velyamov M.T. (2018). Sonochemical Micronization of Taxifolin Aimed at Improving Its Bioavailability in Drinks for Athletes, Human. Sport. Medicine, 18(3), 90–100. DOI: 10.14529/hsm180309</mixed-citation><mixed-citation xml:lang="en">Potoroko I.Yu., Kalinina I.V., Naumenko N.V., Fatkullin R.I., Nenasheva A.V., Uskova D.G., Sonawane S.H., Ivanova D.G., &amp;Velyamov M.T. (2018). Sonochemical Micronization of Taxifolin Aimed at Improving Its Bioavailability in Drinks for Athletes, Human. Sport. Medicine, 18(3), 90–100. DOI: 10.14529/hsm180309</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Rui X., Tan H., Yan Q. (2014). Nanostructured metal sulfides for energy storage. Nanoscale, 6(17), 9889-9924. https://doi.org/10.1039/C4NR03057E</mixed-citation><mixed-citation xml:lang="en">Rui X., Tan H., Yan Q. (2014). Nanostructured metal sulfides for energy storage. Nanoscale, 6(17), 9889-9924. https://doi.org/10.1039/C4NR03057E</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Sano Y. (1999). Antiviral activity of alginate against infection by tobacco mosaic virus. Carbohydrate polymers, 38(2), 183-186. https://doi.org/10.1016/S0144-8617(98)00119-2</mixed-citation><mixed-citation xml:lang="en">Sano Y. (1999). Antiviral activity of alginate against infection by tobacco mosaic virus. Carbohydrate polymers, 38(2), 183-186. https://doi.org/10.1016/S0144-8617(98)00119-2</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sellimi S., Younes I., Ayed H. B., Maalej H., Montero V., Rinaudo M., Nasri M. (2015). Structural, physicochemical and antioxidant properties of sodium alginate isolated from a Tunisian brown seaweed. International Journal of Biological Macromolecules, 72, 1358-1367. https://doi.org/10.1016/j.ijbiomac.2014.10.016</mixed-citation><mixed-citation xml:lang="en">Sellimi S., Younes I., Ayed H. B., Maalej H., Montero V., Rinaudo M., Nasri M. (2015). Structural, physicochemical and antioxidant properties of sodium alginate isolated from a Tunisian brown seaweed. International Journal of Biological Macromolecules, 72, 1358-1367. https://doi.org/10.1016/j.ijbiomac.2014.10.016</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Serrano-Aroca A., Ferrandis-Montesinos M., Wang R. (2021). Antiviral properties of alginate-based biomaterials: promising antiviral agents against SARS-CoV-2. ACS Applied Bio Materials, 4(8), 5897-5907. https://doi.org/10.1021/acsabm.1c00523</mixed-citation><mixed-citation xml:lang="en">Serrano-Aroca A., Ferrandis-Montesinos M., Wang R. (2021). Antiviral properties of alginate-based biomaterials: promising antiviral agents against SARS-CoV-2. ACS Applied Bio Materials, 4(8), 5897-5907. https://doi.org/10.1021/acsabm.1c00523</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Sun Q. L., Li Y., Ni L. Q., Li Y. X., Cui Y. S., Jiang S. L., Dong C. X. (2020a). Structural characterization and antiviral activity of two fucoidans from the brown algae Sargassum henslowianum. Carbohydrate polymers, 229, 115487. https://doi.org/10.1016/j.carbpol.2019.115487</mixed-citation><mixed-citation xml:lang="en">Sun Q. L., Li Y., Ni L. Q., Li Y. X., Cui Y. S., Jiang S. L., Dong C. X. (2020a). Structural characterization and antiviral activity of two fucoidans from the brown algae Sargassum henslowianum. Carbohydrate polymers, 229, 115487. https://doi.org/10.1016/j.carbpol.2019.115487</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sun S. H., Chen Q., Gu H. J., Yang G., Wang Y. X., Huang X. Y., Wang Y. C. (2020b). A mouse model of SARS-CoV-2 infection and pathogenesis. Cell host &amp; microbe, 28(1), 124-133. https://doi.org/10.1016/j.chom.2020.05.020</mixed-citation><mixed-citation xml:lang="en">Sun S. H., Chen Q., Gu H. J., Yang G., Wang Y. X., Huang X. Y., Wang Y. C. (2020b). A mouse model of SARS-CoV-2 infection and pathogenesis. Cell host &amp; microbe, 28(1), 124-133. https://doi.org/10.1016/j.chom.2020.05.020</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sun T., Zhang X., Miao Y., Zhou Y., Shi J., Yan M., Chen A. (2018). Studies on antiviral and immuno-regulation activity of low molecular weight fucoidan from Laminaria japonica. Journal of Ocean University of China, 17(3), 705-711. https://doi.org/10.1007/s11802-018-3794-1</mixed-citation><mixed-citation xml:lang="en">Sun T., Zhang X., Miao Y., Zhou Y., Shi J., Yan M., Chen A. (2018). Studies on antiviral and immuno-regulation activity of low molecular weight fucoidan from Laminaria japonica. Journal of Ocean University of China, 17(3), 705-711. https://doi.org/10.1007/s11802-018-3794-1</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Tang C. H. (2020). Globular proteins as soft particles for stabilizing emulsions: Concepts and strategies. Food Hydrocolloids, 103, 105664. https://doi.org/10.1016/j.foodhyd.2020.105664</mixed-citation><mixed-citation xml:lang="en">Tang C. H. (2020). Globular proteins as soft particles for stabilizing emulsions: Concepts and strategies. Food Hydrocolloids, 103, 105664. https://doi.org/10.1016/j.foodhyd.2020.105664</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Tomori M., Nagamine T., Miyamoto T., Iha M. (2019). Evaluation of the immunomodulatory effects of fucoidan derived from Cladosiphon okamuranus Tokida in mice. Marine drugs, 17(10), 547. https://doi.org/10.3390/md17100547</mixed-citation><mixed-citation xml:lang="en">Tomori M., Nagamine T., Miyamoto T., Iha M. (2019). Evaluation of the immunomodulatory effects of fucoidan derived from Cladosiphon okamuranus Tokida in mice. Marine drugs, 17(10), 547. https://doi.org/10.3390/md17100547</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Torabi P., Hamdami N., Keramat J. (2022). Investigation on total phenolic content, antioxidant activity, and emulsifying capacity of sodium alginate from Nizimuddinia zanardini during microwave-assisted extraction; optimization and statistical modeling. Journal of Food Measurement and Characterization, 16(2), 1549-1558. https://doi.org/10.1007/s11694-021-01255-4</mixed-citation><mixed-citation xml:lang="en">Torabi P., Hamdami N., Keramat J. (2022). Investigation on total phenolic content, antioxidant activity, and emulsifying capacity of sodium alginate from Nizimuddinia zanardini during microwave-assisted extraction; optimization and statistical modeling. Journal of Food Measurement and Characterization, 16(2), 1549-1558. https://doi.org/10.1007/s11694-021-01255-4</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y., Xing M., Cao Q., Ji A., Liang H., Song S. (2019). Biological activities of fucoidan and the factors mediating its therapeutic effects: A review of recent studies. Marine Drugs, 17(3), 183. https://doi.org/10.3390/md17030183</mixed-citation><mixed-citation xml:lang="en">Wang Y., Xing M., Cao Q., Ji A., Liang H., Song S. (2019). Biological activities of fucoidan and the factors mediating its therapeutic effects: A review of recent studies. Marine Drugs, 17(3), 183. https://doi.org/10.3390/md17030183</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">WangZ., Huang Y., Wang M., Wu G., Geng T., Zhao Y., Wu A. (2016). Macroporous calcium alginate aerogel as sorbent for Pb2+ removal from water media. Journal of environmental chemical engineering, 4(3), 3185-3192. https://doi.org/10.1016/j.jece.2016.06.032</mixed-citation><mixed-citation xml:lang="en">WangZ., Huang Y., Wang M., Wu G., Geng T., Zhao Y., Wu A. (2016). Macroporous calcium alginate aerogel as sorbent for Pb2+ removal from water media. Journal of environmental chemical engineering, 4(3), 3185-3192. https://doi.org/10.1016/j.jece.2016.06.032</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Wani T. A., Masoodi F. A., Akhter R., Akram T., Gani A., Shabir N. (2022). Nanoencapsulation of hydroxytyrosol in chitosan crosslinked with sodium bisulfate tandem ultrasonication: Techno-characterization, release and antiproliferative properties. Ultrasonics Sonochemistry, 82, 105900. https://doi.org/10.1016/j.ultsonch.2021.105900</mixed-citation><mixed-citation xml:lang="en">Wani T. A., Masoodi F. A., Akhter R., Akram T., Gani A., Shabir N. (2022). Nanoencapsulation of hydroxytyrosol in chitosan crosslinked with sodium bisulfate tandem ultrasonication: Techno-characterization, release and antiproliferative properties. Ultrasonics Sonochemistry, 82, 105900. https://doi.org/10.1016/j.ultsonch.2021.105900</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Wu S. Y., Parasuraman V., Arunagiri V., Gunaseelan S., Chou H. Y., Anbazhagan R., Prasad, R. (2020). Radioprotective effect of self-assembled low molecular weight Fucoidan–Chitosan nanoparticles. International Journal of Pharmaceutics, 579, 119161. https://doi.org/10.1016/j.ijpharm.2020.119161</mixed-citation><mixed-citation xml:lang="en">Wu S. Y., Parasuraman V., Arunagiri V., Gunaseelan S., Chou H. Y., Anbazhagan R., Prasad, R. (2020). Radioprotective effect of self-assembled low molecular weight Fucoidan–Chitosan nanoparticles. International Journal of Pharmaceutics, 579, 119161. https://doi.org/10.1016/j.ijpharm.2020.119161</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Xu Y. T., Yang T., Liu L. L., Tang, C. H. (2020). One-step fabrication of multifunctional high internal phase pickering emulsion gels solely stabilized by a softer globular protein nanoparticle: S-Ovalbumin. Journal of Colloid and Interface Science, 580, 515-527. https://doi.org/10.1016/j.jcis.2020.07.054</mixed-citation><mixed-citation xml:lang="en">Xu Y. T., Yang T., Liu L. L., Tang, C. H. (2020). One-step fabrication of multifunctional high internal phase pickering emulsion gels solely stabilized by a softer globular protein nanoparticle: S-Ovalbumin. Journal of Colloid and Interface Science, 580, 515-527. https://doi.org/10.1016/j.jcis.2020.07.054</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Zamani S., Malchione N., Selig M. J., Abbaspourrad A. (2018). Formation of shelf stable Pickering high internal phase emulsions (HIPE) through the inclusion of whey protein microgels. Food &amp; function, 9(2), 982-990. https://doi.org/10.1039/C7FO01800B</mixed-citation><mixed-citation xml:lang="en">Zamani S., Malchione N., Selig M. J., Abbaspourrad A. (2018). Formation of shelf stable Pickering high internal phase emulsions (HIPE) through the inclusion of whey protein microgels. Food &amp; function, 9(2), 982-990. https://doi.org/10.1039/C7FO01800B</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H., Ling M. X., Liu Y. L., Tu X. L., Wang F. Y., Li C. Y., Sun W. D. (2013). High oxygen fugacity and slab melting linked to Cu mineralization: evidence from Dexing porphyry copper deposits, southeastern China. The Journal of Geology, 121(3), 289-305. https://doi.org/10.1086/669975</mixed-citation><mixed-citation xml:lang="en">Zhang H., Ling M. X., Liu Y. L., Tu X. L., Wang F. Y., Li C. Y., Sun W. D. (2013). High oxygen fugacity and slab melting linked to Cu mineralization: evidence from Dexing porphyry copper deposits, southeastern China. The Journal of Geology, 121(3), 289-305. https://doi.org/10.1086/669975</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao X., Guo F., Hu J., Zhang L., Xue C., Zhang Z., Li B. (2016). Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica. Thrombosis research, 144, 46-52. https://doi.org/10.1016/j.thromres.2016.03.008</mixed-citation><mixed-citation xml:lang="en">Zhao X., Guo F., Hu J., Zhang L., Xue C., Zhang Z., Li B. (2016). Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica. Thrombosis research, 144, 46-52. https://doi.org/10.1016/j.thromres.2016.03.008</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Zou Y., Guo J., Yin S. W., Wang J. M., Yang X. Q. (2015). Pickering emulsion gels prepared by hydrogen-bonded zein/tannic acid complex colloidal particles. Journal of Agricultural and Food Chemistry, 63(33), 7405-7414. https://doi.org/10.1021/acs.jafc.5b03113</mixed-citation><mixed-citation xml:lang="en">Zou Y., Guo J., Yin S. W., Wang J. M., Yang X. Q. (2015). Pickering emulsion gels prepared by hydrogen-bonded zein/tannic acid complex colloidal particles. Journal of Agricultural and Food Chemistry, 63(33), 7405-7414. https://doi.org/10.1021/acs.jafc.5b03113</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Zvyagintseva T. N., Usoltseva R. V., Shevchenko N. M., Surits V. V., Imbs T. I., Malyarenko O. S., Ermakova S. P. (2021). Structural diversity of fucoidans and their radioprotective effect. Carbohydrate Polymers, 273, 118551. https://doi.org/10.1016/j.carbpol.2021.118551</mixed-citation><mixed-citation xml:lang="en">Zvyagintseva T. N., Usoltseva R. V., Shevchenko N. M., Surits V. V., Imbs T. I., Malyarenko O. S., Ermakova S. P. (2021). Structural diversity of fucoidans and their radioprotective effect. Carbohydrate Polymers, 273, 118551. https://doi.org/10.1016/j.carbpol.2021.118551</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
