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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">spfp</journal-id><journal-title-group><journal-title xml:lang="ru">Хранение и переработка сельхозсырья</journal-title><trans-title-group xml:lang="en"><trans-title>Storage and Processing of Farm Products</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-9669</issn><issn pub-type="epub">2658-767X</issn><publisher><publisher-name>РОСБИОТЕХ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36107/spfp.2023.4.480</article-id><article-id custom-type="elpub" pub-id-type="custom">spfp-480</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИЧЕСКИЕ И ХИМИЧЕСКИЕ МЕТОДЫ ПЕРЕРАБОТКИ СЕЛЬХОЗПРОДУКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHYSICAL AND CHEMICAL METHODS OF FARM RAW MATERIAL PROCESSING</subject></subj-group></article-categories><title-group><article-title>Анализ биологически активных веществ пчелиного маточного молочка и коровьего молозива с целью создания комплексной биологически активной добавки</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of Biologically Active Substances in Bee Royal Jelly and Bovine Colostrum for the Creation of a Complex Biologically Active  Supplement</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8256-0161</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Умиралиева</surname><given-names>Лазат Бекеновна</given-names></name><name name-style="western" xml:lang="en"><surname>Umiraeva</surname><given-names>Lazat Bekenovna</given-names></name></name-alternatives><bio xml:lang="en"><p>Kazakh Research Institute of Food and Processing Industry</p></bio><email xlink:type="simple">l.umiraliyeva@rpf.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-2009-5054</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амангельдин</surname><given-names>Марат Саматович</given-names></name><name name-style="western" xml:lang="en"><surname>Amangeldin</surname><given-names>Marat Samatovich</given-names></name></name-alternatives><email xlink:type="simple">marat.amangeldin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8855-6315</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Танькова</surname><given-names>Нина Леонидовна</given-names></name><name name-style="western" xml:lang="en"><surname>Tankova</surname><given-names>Nina Leonidovna</given-names></name></name-alternatives><email xlink:type="simple">n.tankova@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9444-6833</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ибраихан</surname><given-names>Акниет Толегенкызы</given-names></name><name name-style="western" xml:lang="en"><surname>Ibraikhan</surname><given-names>Akniet Tolegenkyzy</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник</p></bio><email xlink:type="simple">ibraikhan.akniet0195@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6344-4301</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макеева</surname><given-names>Раушан Кыдырхановна</given-names></name><name name-style="western" xml:lang="en"><surname>Makeeva</surname><given-names>Rauhan Kydyrkhanovna</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник </p></bio><email xlink:type="simple">zhanmaer@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6193-5390</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бармак</surname><given-names>Сабырхан Мухитұлы</given-names></name><name name-style="western" xml:lang="en"><surname>Barmak</surname><given-names>Sabyrkhan Mukhituly</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник</p></bio><email xlink:type="simple">sabyr95@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Казахский НИИ перерабатывающей и пищевой промышленности</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>Kazakh Research Institute of Food and Processing Industry</institution><country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>OOO Свеба Дален Рус</institution><country>Казахстан</country></aff><aff xml:lang="en"><institution>Sveba Dahlen Russia</institution><country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>06</day><month>10</month><year>2023</year></pub-date><volume>0</volume><issue>4</issue><fpage>45</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Умиралиева Л.Б., Амангельдин М.С., Танькова Н.Л., Ибраихан А.Т., Макеева Р.К., Бармак С.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Умиралиева Л.Б., Амангельдин М.С., Танькова Н.Л., Ибраихан А.Т., Макеева Р.К., Бармак С.М.</copyright-holder><copyright-holder xml:lang="en">Umiraeva L.B., Amangeldin M.S., Tankova N.L., Ibraikhan A.T., Makeeva R.K., Barmak S.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.spfp-mgupp.ru/jour/article/view/480">https://www.spfp-mgupp.ru/jour/article/view/480</self-uri><abstract><sec><title>Введение</title><p>Введение: Биологически активные вещества, содержащиеся в пчелином маточном молочке и коровьем молозиве, представляют собой ценный источник биологически активных компонентов, которые имеют потенциал для создания инновационных комплексных биологически активных добавок. Дана оценка потребности современного человека в специализированных продуктах. </p></sec><sec><title>Цель</title><p>Цель: разработка технологических решений для создания комплексного БАД —нутрицевтика с использованием маточного молочка пчёл, полученного по разработанной ТОО «КазНИИППП» технологии сбора и адсорбции.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: Коровье молозиво, собранное в первые «0», «6», часов после отёла от здоровых животных, отрицательно реагирующих при исследовании на туберкулез, бруцеллез и лейкоз, третьего отёла, плотностью (1,080–1,045) г/см, рН — от 5,9 до рН 8,3  единиц. Микробиологические показатели исследуемых образцов молозива в соответствии с требованиями ТР ТС 27; маточное молочко пчёл, собранное и адсорбированное по разработанной методике исследователей «КазНИИППП»: биологические активности композиций сырья. В разработанной методике стабилизации маточного молочка были использованы критерии, включающие оценку аминокислотного и витаминного составов. Особое внимание уделялось содержанию 10- гидрокси-2- деценовой кислоты в адсорбированном продукте.</p></sec><sec><title>Результаты</title><p>Результаты: Обоснован выбор нутрцевтических источников и функциональные свойства комплексного БАД – нутрицевтика. Описаны процессы сбора и хранения сырья. Приведены результаты исследований хранения сырья по основным критериям: микробиологической безопасности, титру иммуноглобулинов (IgG) в молозиве, содержанию деценовых кислот в маточном молочке. Полученные результаты послужили основанием для разработки рецептурных композиций БАД. Установлены соотношения пчелиного маточного молочка, и коровьего молозива, дана оценка эффективности комплексной БАД в соответствии с нормативными требованиями, предъявляемыми к БАД ‒ нутрицевтику. </p></sec><sec><title>Выводы</title><p>Выводы: Стандартизация сбора и хранения истинного молозива, стабилизация биологических активностей маточного молочка, полученного с использованием разработанной технологии формирования семьи-воспитательницы и применение мягких методов заморозки и адсорбции обеспечивают создание функциональных композиций маточного молочка и коровьего молозива в контролируемом процессе. Обоснованные технологические решения получения БАД на основе маточного молочка и коровьего молозива не имеют аналогов по композиции функциональных ингредиентов и эффективны с практической точки зрения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction: Biologically active substances found in bee royal jelly and bovine colostrum are a valuable source of active components with potential for creating innovative complex dietary supplements. The modern human need for specialized products is assessed.</p></sec><sec><title>Purpose</title><p>Purpose: To develop technological solutions for creating a comprehensive dietary supplement — nutraceutical using bee royal jelly, collected and adsorbed using a method developed by “KazNIIPPP”. </p></sec><sec><title>Materials and Methods</title><p>Materials and Methods: Bovine colostrum, collected within the first “0”, “6” hours after calving from healthy animals negative for tuberculosis, brucellosis, and leukemia, of the third calving, with a density of (1,080–1,045) g/cm, pH — from 5.9 to 8.3 units. Microbiological indicators of the studied colostrum samples in accordance with the requirements of TR TS 27; bee royal jelly, collected and adsorbed using a method developed by “KazNIIPPP” researchers: biological activities of raw material compositions. The developed method for stabilizing royal jelly included criteria assessing amino acid and vitamin compositions. Special attention was given to the content of 10 hydroxy-2-decenoic acid in the adsorbed product.</p></sec><sec><title>Results</title><p>Results: The choice of nutraceutical sources and functional properties of the complex dietary supplement — nutraceutical are justified. The processes of collection and storage of raw materials are described. Results of the storage of raw materials according to the main criteria are presented: microbiological safety, titers of immunoglobulins (IgG) in colostrum, content of decenoic acids in royal jelly. The obtained results served as a basis for the development of dietary supplement recipes. Ratios of bee royal jelly and bovine colostrum are established, and the effectiveness of the complex dietary supplement is assessed according to the regulatory requirements for dietary supplements - nutraceuticals.</p></sec><sec><title>Conclusions</title><p>Conclusions: Standardization of collection and storage of true colostrum, stabilization of biological activities of royal jelly obtained using the developed technology of forming a caregiver family and the application of gentle methods of freezing and adsorption ensure the creation of functional compositions of royal jelly and bovine colostrum in a controlled process. The substantiated technological solutions for obtaining dietary supplements based on royal jelly and bovine colostrum are unique in terms of the composition of functional ingredients and are effective from a practical point of view.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>маточное молочко</kwd><kwd>коровье молозиво</kwd><kwd>биологически активные добавки</kwd><kwd>семьявоспитательница</kwd><kwd>функциональные композиции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>royal jelly</kwd><kwd>bovine colostrum</kwd><kwd>dietary supplements</kwd><kwd>caregiver family</kwd><kwd>functional compositions</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Финансирование Исследование выполнено при поддержке финансирования научно-технической программы Министерства сельского хозяйства Республики Казахстан на 2021‒2023 годы BR10764970 «Разработка наукоемких технологий глубокой переработки с/х сырья в целях расширения ассортимента и выхода готовой продукции с единицы сырья, а также снижения доли отходов в производстве продукции» в рамках проекта «Разработка технологии производства и переработки маточного пчелиного молочка для пищевой промышленности». Коллектив авторов выражает искреннюю благодарность всем участникам данного научного проекта за помощь и содействие в проведении исследований. Также выражаем благодарность руководству и ученым Казахского НИИ перерабатывающей и пищевой промышленности за помощь и поддержку.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Белов, А.Е., &amp; Исмагилова, А.Ф. (2012). Эффективность применения 9-оксо-2Е-деценовой кислоты для лечения мастита у коров и получения молока высокого санитарного качества. Вестник Башкирского государственного аграрного университета, (2), 20–21.</mixed-citation><mixed-citation xml:lang="en">Gligorevic, S., Petrovic, M., Ivanovic, J., &amp; Sokovic, M. (2019). Analysis of bioactive components in royal jelly. Journal of Agricultural Science and Technology, 21(3), 654-669.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ляйстнер, Л. (1998). Значение барьерной технологии для сохранения качества пищевых продуктов. Мясная индустрия, (2), 23–25.</mixed-citation><mixed-citation xml:lang="en">Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., &amp; Pérez-Alvarez, J. A. (2008). Biological activities of royal jelly - Review. Trends in Food Science &amp; Technology, 19(12), 634-642.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ляйстнер, Л. (1998). Значение барьерной технологии для сохранения качества пищевых продуктов. Мясная индустрия, (3), 31–32.</mixed-citation><mixed-citation xml:lang="en">Morita, H., Ikeda, T., Kajita, K., Fujioka, K., &amp; Mori, I. (2018). Composition and functional properties of royal jelly: A review. Foods, 7(6), 92.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Орлов, Б.Н., &amp; Асафова, Н.Н. (2002). Эволюционнофизиологические подходы к анализу механизмов действия биологически активных веществ пчелиной семьи. В Апитерапия сегодня (с. 16–18). Рыбное: НИИП.</mixed-citation><mixed-citation xml:lang="en">National Center for Biotechnology Information. PubChem Compound Database; CID=12560, https://pubchem. ncbi.nlm.nih.gov/compound/12560 (accessed Nov. 25, 2016).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Позняковский, В. М., Чугунова, О. В., &amp; Тамова, М. Ю. (2023). Пищевые ингредиенты и биологически активные добавки. НИЦ ИНФРА-М.</mixed-citation><mixed-citation xml:lang="en">Miguel, M. G., Nunes, S., &amp; Dandlen, S. A. (2018). Bioactive Components of Royal Jelly Review. Journal of Food Science, 83(3), 757-764.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Тутельян, В.А. (2001). Биологически активные добавки к пище в профилактическом и лечебном питании. Эволюция взглядов и подходов. V Международный симпозиум по БАД к пище и проблемам здоровья семьи (с. 3–5). Красноярск: Арт лайф.</mixed-citation><mixed-citation xml:lang="en">Anand, A., Sharma, S., Kumar, R., &amp; Gill, B. K. (2019). Therapeutic Uses of Bee Pollen: A Review. Journal of Medicinal Food, 22(5), 412-424.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Тутельян, В.А. (2004). Питание и здоровье. Пищевая промышленность, 5(7).</mixed-citation><mixed-citation xml:lang="en">Fokt, H. F., Pereira, A., Ferreira, A., &amp; Rijo, P. (2018). Antimicrobial and Immunomodulatory Properties of Bee Propolis: A Review. Trends in Food Science &amp; Technology, 71, 210-218.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Фесенко, Л.М., &amp; Арипов, О.А. (2007). Использование флавоноидов для коррекции нарушения функции печени при экспериментальном хроническом токсическом гепатите. Юбилейная Российская научная конференция, посвященная 175-летию со дня рождения С.П.Боткина (с. 335). Санкт-Петербург: РАМН.</mixed-citation><mixed-citation xml:lang="en">Kelly, G. S. (2020). Health-Promoting Effects of Colostrum: A Review. Journal of the American College of Nutrition, 39(8), 732-751.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Alu’datt, M. H., Rababah, T., Obaidat, M., Ereifej, K., Alhamad, M., Mhaidat, N. M., J. Andrade, A. Johargy, Ayadi, W. (2015). Probiotics in milk as functional food: Characterization and nutraceutical properties of extracted phenolics and peptides from fermented skimmed milk inoculated with royal jelly. Journal of Food Safety. https://doi.org/10.1111/jfs.12201</mixed-citation><mixed-citation xml:lang="en">Patel, R. D., Mehta, B. M., Goyal, R. K., Patel, P. R., &amp; Pandya, H. V. (2019). Bovine Colostrum: An Emerging Nutraceutical. International Journal of Nutrition, Pharmacology, Neurological Diseases, 9(2), 32-38.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Anand, A., Sharma, S., Kumar, R., &amp; Gill, B. K. (2019). Therapeutic uses of bee pollen: A review. Journal of Medicinal Food, 22(5), 412–424. https://doi.org/10.1089/jmf.2018.0144</mixed-citation><mixed-citation xml:lang="en">Szweda, P., Gucwa, K., Kurpios-Piec, D., &amp; Pawlikowska, M. (2020). Bioactive Peptides from Bee Products for Health Benefits: A Review. Nutrients, 12(7), 1840.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Awuchi, G. G., Igwe, V. S., Amagwula, O. I., &amp; Echeta, C. K. (2020). Health benefits of micronutrients (vitamins and minerals) and their associated deficiency diseases: A systematic review. International Journal of Food Science, 3(1), 1–32. https://doi.org/10.47604/ijf.1024</mixed-citation><mixed-citation xml:lang="en">da Silva, P. M., Gauche, C., Gonzaga, L. V., Costa, A. C. O., &amp; Fett, R. (2019). Health Benefits of Bee Products and Their Constituents: A Review. Journal of Agricultural and Food Chemistry, 67(34), 7831-7843.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Back, P. J., Hickson, R., Sneddon, N. W., Coleman, L. W., Laven,R. A. (2019). Association of bacterial contamination of colostrum with passive immunity and growth rates in dairy heifer calves. New Zealand Journal of Animal Science and Production, 79, 149–152.</mixed-citation><mixed-citation xml:lang="en">Bogdanov, S., Jurendic, T., Sieber, R., &amp; Gallmann, P. (2017). Biological and Therapeutic Properties of Bee Pollen: A Review. Journal of Pharmacy and Pharmacology, 69(3), 225-235.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bogdanov, S., Jurendic, T., Sieber, R., &amp; Gallmann, P. (2017). Biological and therapeutic properties of bee pollen: A review. Journal of Pharmacy and Pharmacology, 69(3), 225– 235.https://doi.org/10.1111/jphp.12645</mixed-citation><mixed-citation xml:lang="en">Rusznyák, Á., Sujbert, K., Bakonyi, T., &amp; Szöke, É. (2018). Biological Activities of Royal Jelly - Review. Acta Veterinaria Hungarica, 66(4), 535-544.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chandrasekar, S., Rajagopalan, S. M., Ayyaswami, S. (2023). Standardization of mass queen rearing techniques in Indian Honey Bees. Madras Agricultural Journal, September(7–9), 2023.https://doi.org/10.29321/MAJ.10.200007</mixed-citation><mixed-citation xml:lang="en">Pakkanen, R., Aalto, J., &amp; Virtanen, E. (2017). Colostrum and Its Benefits: A Review. Journal of the Science of Food and Agriculture, 97(6), 1592-1604.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">da Silva, P. M., Gauche, C., Gonzaga, L. V., Costa, A. C. O., &amp; Fett, R. (2019). Health benefits of bee products and their constituents: A review. Journal of Agricultural and Food Chemistry, 67(34), 7831–7843. https://doi.org/10.1021/acs.jafc.9b02679</mixed-citation><mixed-citation xml:lang="en">Pithua, P. Efficacy of feeding a lacteal-derived colostrum replacer or pooled maternal colostrum with a low IgG concentration for prevention of failure of passive transfer in dairy calves / P. Pithua, S.S. Aly, D.M. Hainesetal // J. Am. Vet. Med. Assoc. – 2013. – Vol. 243, № 2. – P. 277–282.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Das, J. K., Salam, R. A., Mahmood, S., Moin, A., Kumar, R., Mukhtar, K., Z. Lassi, Bhutta, Z. (2019). Food fortification with multiple micronutrients: Impact on health outcomes in general population. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD011400.pub2</mixed-citation><mixed-citation xml:lang="en">Davidson, G.P. Passive protection against diarrheal disease / G.P. Davidson // J. Ped. Gastroint. Nutr. – 1996. – Vol. 23. – P. 207–212.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Davidson, G. P. (1996). Passive protection against diarrheal disease. Journal of Pediatric Gastroenterology and Nutrition, 23, 207–212.</mixed-citation><mixed-citation xml:lang="en">Ляйстнер Л. Значение барьерной технологии для сохранения качества пищевых продуктов // Мясная индустрия, 1998, № 2. С. 23-25; № 3. - С. 3132.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Dubtsova, G., Lomakin, A., Kusova, I., Bulannikova, E., Bystrov, D. (2022). Biologically active substances from powdered barberry and viburnum. Food Processing. http://doi.org/10.21603/2074-9414-2021-4-779-783</mixed-citation><mixed-citation xml:lang="en">Noda N., Umebayashi K., Nakatani T., Miyahara K., Ishiyama K. Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera) // Lipids. – 2005. – Vol. 40. № 8. – P. 833–838. https://doi.org/10.1007/s11745-005-1445-6.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dundar, A. N., Cinar, A., Altuntas, S., Ulubayram, N., Taner, G., Dagdelen, A. F., Demircan, H., &amp; Oral, R. A. (2022). The role of microencapsulation in maintaining biological activity of royal jelly: comparison with biological activity and bioaccessibility of microencapsulated, fresh and lyophilized forms during storage. Journal of the Science of Food and Agriculture. https://doi.org/10.1002/jsfa.11905</mixed-citation><mixed-citation xml:lang="en">National Center for Biotechnology Information. PubChem Compound Database; CID=5280963, https://pubchem. ncbi.nlm.nih.gov/compound/5280963 (accessed Nov. 9, 2016).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fokt, H. F., Pereira, A., Ferreira, A., &amp; Rijo, P. (2018). Antimicrobial and immunomodulatory properties of bee propolis: A review. Trends in Food Science &amp; Technology, 71, 210–218.https://doi.org/10.1016/j.tifs.2017.11.008</mixed-citation><mixed-citation xml:lang="en">National Center for Biotechnology Information. PubChem Compound Database; CID=379, https://pubchem.ncbi. nlm.nih.gov/compound/379 (accessed Nov. 15, 2016).</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ivanova, T., Popova, T., &amp; Balkanska, R. (2022). Effect of the Dietary Royal Jelly Supplementation in Ewes of Bulgarian Dairy Synthetic Population on the Body Weight of the Lambs and the Milk Composition. International Journal of Innovative Approaches in Agricultural Research, 6(4), 417– 425. https://doi.org/10.29329/ijiaar.2022.506.12</mixed-citation><mixed-citation xml:lang="en">Townsend G.F., Morgan J.F., Tolnai S., Hazlett B., Morton H.J., Shuel R.W. Studies on the in vitro antitumor activity of fatty acids I. 10-hydroxy-2-decenoic acid from royal jelly // Cancer research. – 1960. – Vol. 20, № 4. – Р. 503–510.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Janota-Bassalik, L., Ryniewicz, Z., Pietraszek, A., Zajac, M., Albrecht, A., Pietrowska, E., &amp; Zalewska, M. (1975). Pathogenic microflora in naturally and experimentally infected mammary glands of cows. Vet Med Nauki, 12(3), 77–80.</mixed-citation><mixed-citation xml:lang="en">Townsend G.F., William H.B., Felauer E.E., Barbara H. Studies on the in vitro antitumor activity of fatty acids: IV. The esters of acids closely related to 10-hydroxy-2-decenoic acid from royal jelly against transplantable mouse leukemia // Canadian journal of Biochemistry and Physiology. – 1961. – Vol. 39, № 11. – Р. 1765–1770.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kelly, G. S. (2020). Health-promoting effects of colostrum: A review. Journal of the American College of Nutrition, 39(8), 732–751. https://doi.org/10.1080/07315724.2020.1712247</mixed-citation><mixed-citation xml:lang="en">Kelly, G. S. (2020). Health-promoting effects of colostrum: A review. Journal of the American College of Nutrition, 39(8), 732–751. https://doi.org/10.1080/07315724.2020.1712247</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Luo, Y., Kong, Z., Yang, B., He, F., Huan, C., Li, J., &amp; Yi, K. (2023). Relationship between microflora changes and mammary lipid metabolism in dairy cows with mastitis. Animals, 13(17), 2773. https://doi.org/10.3390/ani13172773</mixed-citation><mixed-citation xml:lang="en">Luo, Y., Kong, Z., Yang, B., He, F., Huan, C., Li, J., &amp; Yi, K. (2023). Relationship between microflora changes and mammary lipid metabolism in dairy cows with mastitis. Animals, 13(17), 2773. https://doi.org/10.3390/ani13172773</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Miguel, M. G., Nunes, S., &amp; Dandlen, S. A. (2018). Bioactive components of royal jelly: Review. Journal of Food Science, 83(3), 757–764. https://doi.org/10.1111/1750-3841.14060</mixed-citation><mixed-citation xml:lang="en">Miguel, M. G., Nunes, S., &amp; Dandlen, S. A. (2018). Bioactive components of royal jelly: Review. Journal of Food Science, 83(3), 757–764. https://doi.org/10.1111/1750-3841.14060</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Morin, M. P., Dubuc, J., Freycon, P., &amp; Buczinski, S. (2021). Diagnostic accuracy of the Petrifilm culture system for identifying colostrum with excessive bacterial contamination in Quebec dairy herds. Journal of Dairy Science, 104(4), 4923–4928. https://doi.org/10.3168/jds.2020-19474</mixed-citation><mixed-citation xml:lang="en">Morin, M. P., Dubuc, J., Freycon, P., &amp; Buczinski, S. (2021). Diagnostic accuracy of the Petrifilm culture system for identifying colostrum with excessive bacterial contamination in Quebec dairy herds. Journal of Dairy Science, 104(4), 4923–4928. https://doi.org/10.3168/jds.2020-19474</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Noda, N., Umebayashi, K., Nakatani, T., Miyahara, K., &amp; Ishiyama, K. (2005). Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera). Lipids, 40(8), 833–838. https://doi.org/10.1007/s11745-005-1445-6</mixed-citation><mixed-citation xml:lang="en">Noda, N., Umebayashi, K., Nakatani, T., Miyahara, K., &amp; Ishiyama, K. (2005). Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera). Lipids, 40(8), 833–838. https://doi.org/10.1007/s11745-005-1445-6</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pakkanen, R., Aalto, J., &amp; Virtanen, E. (2017). Colostrum and its benefits: A review. Journal of the Science of Food and Agriculture, 97(6), 1592–1604. https://doi.org/10.1002/ jsfa.8227</mixed-citation><mixed-citation xml:lang="en">Pakkanen, R., Aalto, J., &amp; Virtanen, E. (2017). Colostrum and its benefits: A review. Journal of the Science of Food and Agriculture, 97(6), 1592–1604. https://doi.org/10.1002/ jsfa.8227</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Patel, R. D., Mehta, B. M., Goyal, R. K., Patel, P. R., &amp; Pandya, H. V. (2019). Bovine colostrum: An emerging nutraceutical. International Journal of Nutrition, Pharmacology, Neurological Diseases, 9(2), 32–38. https://doi.org/10.4103/ijnpnd.ijnpnd_36_19</mixed-citation><mixed-citation xml:lang="en">Patel, R. D., Mehta, B. M., Goyal, R. K., Patel, P. R., &amp; Pandya, H. V. (2019). Bovine colostrum: An emerging nutraceutical. International Journal of Nutrition, Pharmacology, Neurological Diseases, 9(2), 32–38. https://doi.org/10.4103/ijnpnd.ijnpnd_36_19</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Pithua, P., Aly, S. S., Haines, D. M., et al. (2013). Efficacy of feeding a lacteal-derived colostrum replacer or pooled maternal colostrum with a low IgG concentration for prevention of failure of passive transfer in dairy calves. Journal of the American Veterinary Medical Association, 243(2), 277–282. https://doi.org/10.2460/javma.243.2.277</mixed-citation><mixed-citation xml:lang="en">Pithua, P., Aly, S. S., Haines, D. M., et al. (2013). Efficacy of feeding a lacteal-derived colostrum replacer or pooled maternal colostrum with a low IgG concentration for prevention of failure of passive transfer in dairy calves. Journal of the American Veterinary Medical Association, 243(2), 277–282. https://doi.org/10.2460/javma.243.2.277</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Rusznyák, Á., Sujbert, K., Bakonyi, T., &amp; Szöke, É. (2018). Biological activities of royal jelly: Review. Acta Veterinaria Hungarica, 66(4), 535–544. https://doi.org/10.1556/004.2018.050</mixed-citation><mixed-citation xml:lang="en">Rusznyák, Á., Sujbert, K., Bakonyi, T., &amp; Szöke, É. (2018). Biological activities of royal jelly: Review. Acta Veterinaria Hungarica, 66(4), 535–544. https://doi.org/10.1556/004.2018.050</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Sagona, S., Coppola, F., Giannaccini, G., Betti, L., Palego, L., Tafi, E., Casini, L., Piana, L., Dall’Olio, R., Felicioli, A. (2022). Impact of different storage temperature on the enzymatic activity of apis mellifera royal jelly. Foods, 11(20), 3165. https://doi.org/10.3390/foods11203165</mixed-citation><mixed-citation xml:lang="en">Sagona, S., Coppola, F., Giannaccini, G., Betti, L., Palego, L., Tafi, E., Casini, L., Piana, L., Dall’Olio, R., Felicioli, A. (2022). Impact of different storage temperature on the enzymatic activity of apis mellifera royal jelly. Foods, 11(20), 3165. https://doi.org/10.3390/foods11203165</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sari, E., Mahira, K. F., Patel, D., Chua, L. S., Pratami, D., &amp; Sahlan, M. (2021). Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products. Heliyon, 7(5), E06912. https://doi.org/10.1016/j.heliyon.2021.e06912</mixed-citation><mixed-citation xml:lang="en">Sari, E., Mahira, K. F., Patel, D., Chua, L. S., Pratami, D., &amp; Sahlan, M. (2021). Metabolome analysis and chemical profiling of Indonesian royal jellies as the raw material for cosmetic and bio-supplement products. Heliyon, 7(5), E06912. https://doi.org/10.1016/j.heliyon.2021.e06912</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sokolova, O.V., Bezborodova, N.A., Lysova, Y.Y., &amp; Pechura, E.V. (2021). Characteristics of species composition, biochemical and pathogenic nature of the microbiota of mammary gland and the reproductive tract in dairy cows. E3S Web of Conferences, 282, 03017.https://doi.org/10.1051/e3sconf/202128203017</mixed-citation><mixed-citation xml:lang="en">Sokolova, O.V., Bezborodova, N.A., Lysova, Y.Y., &amp; Pechura, E.V. (2021). Characteristics of species composition, biochemical and pathogenic nature of the microbiota of mammary gland and the reproductive tract in dairy cows. E3S Web of Conferences, 282, 03017.https://doi.org/10.1051/e3sconf/202128203017</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Szweda, P., Gucwa, K., Kurpios-Piec, D., &amp; Pawlikowska, M. (2020). Bioactive peptides from bee products for health benefits: A review. Nutrients, 12(7), 1840. https://doi.org/10.3390/nu12071840</mixed-citation><mixed-citation xml:lang="en">Szweda, P., Gucwa, K., Kurpios-Piec, D., &amp; Pawlikowska, M. (2020). Bioactive peptides from bee products for health benefits: A review. Nutrients, 12(7), 1840. https://doi.org/10.3390/nu12071840</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Townsend, G. F., Morgan, J. F., Tolnai, S., Hazlett, B., Morton, H.J., &amp; Shuel, R. W. (1960). Studies on the in vitro antitumor activity of fatty acids I. 10-hydroxy-2-decenoic acid from royal jelly. Cancer Research, 20(4), 503–510.</mixed-citation><mixed-citation xml:lang="en">Townsend, G. F., Morgan, J. F., Tolnai, S., Hazlett, B., Morton, H.J., &amp; Shuel, R. W. (1960). Studies on the in vitro antitumor activity of fatty acids I. 10-hydroxy-2-decenoic acid from royal jelly. Cancer Research, 20(4), 503–510.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Townsend, G. F., William, H. B., Felauer, E. E., &amp; Barbara, H. (1961). Studies on the in vitro antitumor activity of fatty acids: IV. The esters of acids closely related to 10-hydroxy2-decenoic acid from royal jelly against transplantable mouse leukemia. Canadian Journal of Biochemistry and Physiology, 39(11), 1765–1770.</mixed-citation><mixed-citation xml:lang="en">Townsend, G. F., William, H. B., Felauer, E. E., &amp; Barbara, H. (1961). Studies on the in vitro antitumor activity of fatty acids: IV. The esters of acids closely related to 10-hydroxy2-decenoic acid from royal jelly against transplantable mouse leukemia. Canadian Journal of Biochemistry and Physiology, 39(11), 1765–1770.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Li, L., Wang, P., Xu, Y., Wu, X., &amp; Liu, X. (2022). Effect of Trehalose on the Physicochemical Properties of Freeze-Dried Powder of Royal Jelly of Northeastern Black Bee. Coatings, 12(2), 173.https://doi.org/10.3390/coatings12020173</mixed-citation><mixed-citation xml:lang="en">Li, L., Wang, P., Xu, Y., Wu, X., &amp; Liu, X. (2022). Effect of Trehalose on the Physicochemical Properties of Freeze-Dried Powder of Royal Jelly of Northeastern Black Bee. Coatings, 12(2), 173.https://doi.org/10.3390/coatings12020173</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Spanidi, E., Athanasopoulou, S., Liakopoulou, A., Chaidou,A., Hatziantoniou, S., &amp; Gardikis, K. (2022). Royal Jelly Components Encapsulation in a Controlled Release System—Skin Functionality, and Biochemical Activity for Skin Applications. Pharmaceuticals, 15(8), 907.https://doi.org/10.3390/ph15080907</mixed-citation><mixed-citation xml:lang="en">Spanidi, E., Athanasopoulou, S., Liakopoulou, A., Chaidou,A., Hatziantoniou, S., &amp; Gardikis, K. (2022). Royal Jelly Components Encapsulation in a Controlled Release System—Skin Functionality, and Biochemical Activity for Skin Applications. Pharmaceuticals, 15(8), 907.https://doi.org/10.3390/ph15080907</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ghadimi-Garjan, R., Javadi, A., Jafarizadeh-Malmiri, H., Anarjan, N., &amp; Mirzaei, H. (2023). Lyophilized royal jelly preparation in nanoscale and evaluation of its physicochemical properties and bactericidal activity. Food Science and Nutrition, 11(6), 3404–3413.</mixed-citation><mixed-citation xml:lang="en">Ghadimi-Garjan, R., Javadi, A., Jafarizadeh-Malmiri, H., Anarjan, N., &amp; Mirzaei, H. (2023). Lyophilized royal jelly preparation in nanoscale and evaluation of its physicochemical properties and bactericidal activity. Food Science and Nutrition, 11(6), 3404–3413.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Honda, Y., Araki, Y., Hata, T., Ichihara, K., Ito, M., Tanaka, M., &amp; Honda, S. (2015). 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. Journal of Aging Research, Volume 2015, Article ID 425261. https://doi.org/10.1155/2015/425261</mixed-citation><mixed-citation xml:lang="en">Honda, Y., Araki, Y., Hata, T., Ichihara, K., Ito, M., Tanaka, M., &amp; Honda, S. (2015). 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. Journal of Aging Research, Volume 2015, Article ID 425261. https://doi.org/10.1155/2015/425261</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Khazaei, M., Ansarian, A., &amp; Ghanbari, E. (2018). New Findings on Biological Actions and Clinical Applications of Royal Jelly: A Review. Journal of Dietary Supplements, 15(5), 757–775. https://doi.org/10.1080/19390211.2017.1363843</mixed-citation><mixed-citation xml:lang="en">Khazaei, M., Ansarian, A., &amp; Ghanbari, E. (2018). New Findings on Biological Actions and Clinical Applications of Royal Jelly: A Review. Journal of Dietary Supplements, 15(5), 757–775. https://doi.org/10.1080/19390211.2017.1363843</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
