Amoxicillin and Acidic Acid: Effective Medicines for Animal Health Protection

Providing the domestic livestock and poultry farming actively developing in recent years with effective and inexpensive medicines for animals, including for increasing the competitiveness of domestic products in export by increasing the profitability of production and reducing the cost of veterinary and sanitary measures is one of the priority tasks of the Strategy. scientific and technological development of the Russian Federation. One of the key tasks for creating safe and high-quality food is the development, production and rational use of effective and safe means of protecting the health of farm animals. The purpose of our review is to substantiate the development of innovative means of protecting the health of farm animals through the use of low doses of the antibiotic amoxicillin in combination with succinic acid. The prospects for the development of veterinary drugs based on amoxicillin are due to a wide spectrum of bactericidal action against aerobic gram-positive and gram-negative bacteria, good solubility, bioavailability, rapid absorption from the gastrointestinal tract, which is not influenced by food intake, high resistance to gastric juice, which allows you to effectively use it not only in injectable, but also in oral dosage forms. But the susceptibility of bacteria to antibiotics is seriously reduced when bacterial cells form the so-called biofilms - resistant conglomerate colonies surrounded by extracellular polymeric substance. The dense structure of cell colonies in biofilms and the presence of a polymer matrix covering them significantly complicates the contact of antibiotics with bacterial cells. Because of this, the resistance of bacteria to antimicrobial drugs in biofilms is much higher compared to single bacteria. Therefore, infections associated with the formation of biofilm pathogens are much more difficult to treat with antibiotics and often become recurrent. Given the prevalence of such infections, it is advisable to develop an antibacterial drug containing the antibiotic amoxicillin in combination with a component capable of causing the destruction of biofilms. This component is succinic acid. The mechanism of this phenomenon is explained by the fact that succinic acid promotes the destruction of bacterial films and, thus, an increase in the area of contact of antibiotics with bacterial cells.

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